ABAEnrichment 1.6.0

Gene expression enrichment in human brain regions

Released Apr 23, 2017 by Steffi Grote

This package cannot yet be used with Renjin it depends on other packages which are not available: ABAData and gplots 3.0.1


gplots 3.0.1 Rcpp gtools 3.5.0

The package ABAEnrichment is designed to test for enrichment of user defined candidate genes in the set of expressed genes in different human brain regions. The core function 'aba_enrich' integrates the expression of the candidate gene set (averaged across donors) and the structural information of the brain using an ontology, both provided by the Allen Brain Atlas project. 'aba_enrich' interfaces the ontology enrichment software FUNC to perform the statistical analyses. Additional functions provided in this package like 'get_expression' and 'plot_expression' facilitate exploring the expression data. From version 1.3.5 onwards genomic regions can be provided as input, too; and from version 1.5.9 onwards the function 'get_annotated_genes' offers an easy way to obtain annotations of genes to enriched or user-defined brain regions.



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