BioConductor
ASSIGN 1.16.0
Adaptive Signature Selection and InteGratioN (ASSIGN)
Released Oct 30, 2014 by Ying Shen
Dependencies
sva 3.28.0 ggplot2 3.0.0 Rlab 2.15.1 gplots 3.0.1 msm 1.6.6
ASSIGN is a computational tool to evaluate the pathway deregulation/activation status in individual patient samples. ASSIGN employs a flexible Bayesian factor analysis approach that adapts predetermined pathway signatures derived either from knowledge-based literature or from perturbation experiments to the cell-/tissue-specific pathway signatures. The deregulation/activation level of each context-specific pathway is quantified to a score, which represents the extent to which a patient sample encompasses the pathway deregulation/activation signature.