dfpk 3.5.1
Bayesian Dose-Finding Designs using Pharmacokinetics (PK) for Phase I Clinical Trials
Released Nov 9, 2018 by Artemis Toumazi
This package cannot yet be used with Renjin it depends on other packages which are not available:
ggplot2 3.1.0 and
rstan 2.18.2
Dependencies
rstan 2.18.2
ggplot2 3.1.0
PK 1.3-4
Rcpp
dfcrm 0.2-2
StanHeaders 2.18.0
BH 1.66.0-1
RcppEigen 0.3.3.4.0
Statistical methods involving PK measures are provided, in the dose allocation process during a Phase I clinical trials. These methods, proposed by Ursino et al, (2017) , enter pharmacokinetics (PK) in the dose finding designs in different ways, including covariates models, dependent variable or hierarchical models. This package provides functions to generate data from several scenarios and functions to run simulations which their objective is to determine the maximum tolerated dose (MTD).
