drugCombo 1.1.0
Drug Interaction Modeling Based on Loewe Additivity Following Harbron's Approach
Released Jun 18, 2019 by Maxim Nazarov
This package cannot yet be used with Renjin it depends on other packages which are not available:
BIGL 1.4.1 and
rgl 0.100.24
Dependencies
BIGL 1.4.1
rgl 0.100.24
ggplot2 3.2.0
nlme 3.1-140
minpack.lm 1.2-1
Deriv 3.8.5
Perform assessment of synergy/antagonism for drug combinations based on the Loewe additivity model, following Harbron's approach (Statistics in Medicine, 2010, ). The package allows flexible modeling of the drug interaction index and supports "2-stage" estimation in addition to "1-stage" estimation, including bootstrap-based confidence intervals. The method requires data on the monotherapy responses and the package accommodates both checkerboard and ray designs. Functions are available for graphical exploration of model goodness-of-fit and diagnostics, as well as for synergy/antagonism assessment in 2D and 3D.
