CRAN
wTO 1.6.3
Computing Weighted Topological Overlaps (wTO) & Consensus wTO Network
Released Nov 17, 2018 by Deisy Morselli Gysi
Dependencies
shiny 1.2.0 data.table 1.11.8 reshape2 1.4.3 igraph 1.2.2 plyr 1.8.4 visNetwork 2.0.4 magrittr 1.5 som 0.3-5.1
Computes the Weighted Topological Overlap with positive and negative signs (wTO) networks given a data frame containing the mRNA count/ expression/ abundance per sample, and a vector containing the interested nodes of interaction (a subset of the elements of the full data frame). It also computes the cut-off threshold or p-value based on the individuals bootstrap or the values reshuffle per individual. It also allows the construction of a consensus network, based on multiple wTO networks. The package includes a visualization tool for the networks. More about the methodology can be found at