wTO 1.6.3

Computing Weighted Topological Overlaps (wTO) & Consensus wTO Network

Released Nov 17, 2018 by Deisy Morselli Gysi

This package cannot yet be used with Renjin it depends on other packages which are not available: data.table 1.11.8 and shiny 1.2.0 An older version of this package is more compatible with Renjin.


shiny 1.2.0 data.table 1.11.8 reshape2 1.4.3 igraph 1.2.2 plyr 1.8.4 visNetwork 2.0.4 magrittr 1.5 som 0.3-5.1

Computes the Weighted Topological Overlap with positive and negative signs (wTO) networks given a data frame containing the mRNA count/ expression/ abundance per sample, and a vector containing the interested nodes of interaction (a subset of the elements of the full data frame). It also computes the cut-off threshold or p-value based on the individuals bootstrap or the values reshuffle per individual. It also allows the construction of a consensus network, based on multiple wTO networks. The package includes a visualization tool for the networks. More about the methodology can be found at .