BioConductor
LineagePulse 1.0.0
Differential expression analysis and model fitting for single-cell RNA-seq data
Released Oct 9, 2017 by David S Fischer
Dependencies
ComplexHeatmap 1.18.1 ggplot2 3.0.0 SingleCellExperiment 1.2.0 knitr 1.20 circlize 0.4.4 RColorBrewer 1.1-2 BiocParallel 1.14.2 SummarizedExperiment 1.10.1 gplots 3.0.1 Matrix 1.2-14
LineagePulse is a differential expression and expression model fitting package tailored to single-cell RNA-seq data (scRNA-seq). LineagePulse accounts for batch effects, drop-out and variable sequencing depth. One can use LineagePulse to perform longitudinal differential expression analysis across pseudotime as a continuous coordinate or between discrete groups of cells (e.g. pre-defined clusters or experimental conditions). Expression model fits can be directly extracted from LineagePulse.